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A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Assess Safety, Tolerability and Antitumor Activities of the Combination of BGB-3111 With BGB-A317 in Subjects With B-Cell Lymphoid Malignancies

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Trial Profile

A Phase 1b, Open Label, Multiple Dose, Dose Escalation and Expansion Study to Assess Safety, Tolerability and Antitumor Activities of the Combination of BGB-3111 With BGB-A317 in Subjects With B-Cell Lymphoid Malignancies

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 20 Jan 2023

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At a glance

  • Drugs Tislelizumab (Primary) ; Zanubrutinib (Primary)
  • Indications B-cell lymphoma; Chronic lymphocytic leukaemia; CNS cancer; Diffuse large B cell lymphoma; Follicular lymphoma; Mantle-cell lymphoma; Marginal zone B-cell lymphoma; Non-Hodgkin's lymphoma; Richter's syndrome
  • Focus Adverse reactions
  • Sponsors BeiGene

    • Most Recent Events

    • 13 Dec 2022 Results assessing The antitumor efficacy of zanubrutinib and tislelizumab combination therapy has been demonstrated in patients with B-cell malignancies presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 16 Mar 2022 The primary endpoint Dose Expansion: Safety and tolerability: CTCAE v.4.03 was removed, according to ClinicalTrials.gov record.
    • 03 Mar 2021 Status changed from active, no longer recruiting to completed.
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