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D-ALBA Front-Line Sequential Treatment of Adult Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients With Dasatinib and the Bispecific Monoclonal Antibody Blinatumomab

Trial Profile

D-ALBA Front-Line Sequential Treatment of Adult Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL) Patients With Dasatinib and the Bispecific Monoclonal Antibody Blinatumomab

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 23 Jan 2024

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At a glance

  • Drugs Blinatumomab (Primary) ; Dasatinib (Primary) ; Dexamethasone; Levetiracetam; Prednisone
  • Indications Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Therapeutic Use
  • Acronyms D-ALBA; LAL 2116
  • Most Recent Events

    • 12 Dec 2023 final long-term results presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 12 Dec 2023 Results of a multilevel propensity score weighting analysis comparing rates of hematologic CR in four trials: LAL0904, LAL1205, LAL1509 and LAL2116 presented at the 65th American Society of Hematology Annual Meeting and Exposition
    • 15 Jun 2023 Results deriving samples from this study evaluating whether digital droplet PCR (ddPCR) is at least as sensitive as Sanger sequencing (SS) for the detection of the T315Imutation, and if the ddPCR can detect the mutation also at very low levels of minimal residual disease (MRD),ultimately anticipating molecular relapse, presented at the 28th Congress of the European Haematology Association
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