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Safety Evaluations of Nivolumab (Anti-PD-1) Added To Chemotherapy (CRT) Platforms In Patients With Intermediate And High-Risk Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma

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Trial Profile

Safety Evaluations of Nivolumab (Anti-PD-1) Added To Chemotherapy (CRT) Platforms In Patients With Intermediate And High-Risk Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 14 Mar 2023

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At a glance

  • Drugs Nivolumab (Primary) ; Cetuximab; Cisplatin; Ropidoxuridine
  • Indications Head and neck cancer; Hypopharyngeal cancer; Laryngeal cancer; Mouth neoplasm; Oropharyngeal cancer; Squamous cell cancer
  • Focus Adverse reactions

    • Most Recent Events

    • 15 Mar 2023 Results (n=39) assessing the safety of nivolumab concomitant with 70 Gy intensity modulated radiation therapy and weekly cisplatin (arm 1), every 3-week cisplatin (arm 2), cetuximab (arm 3), or alone for platinum-ineligible patients (arm 4) in newly diagnosed intermediate- or high-risk locoregionally advanced head and neck squamous cell carcinoma, published in the International Journal of Radiation Oncology, Biology, Physics.
    • 22 Nov 2022 Status changed from active, no longer recruiting to completed.
    • 05 Jun 2019 Planned End Date changed from 1 Mar 2021 to 1 Dec 2023.
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