An Open-Label, Dose-Finding and Proof of Concept Study of the PD-L1 Probody Therapeutic , CX-072, as Monotherapy and in Combination With Yervoy (Ipilimumab) or With Zelboraf (Vemurafenib) in Subjects With Advanced or Recurrent Solid Tumors or Lymphomas

Trial Profile

An Open-Label, Dose-Finding and Proof of Concept Study of the PD-L1 Probody Therapeutic , CX-072, as Monotherapy and in Combination With Yervoy (Ipilimumab) or With Zelboraf (Vemurafenib) in Subjects With Advanced or Recurrent Solid Tumors or Lymphomas

Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 04 Dec 2017

At a glance

  • Drugs CX 072 (Primary) ; Ipilimumab (Primary) ; Vemurafenib (Primary)
  • Indications Lymphoma; Solid tumours
  • Focus Adverse reactions; First in man; Proof of concept
  • Acronyms PROCLAIM-CX-072
  • Sponsors CytomX Therapeutics
  • Most Recent Events

    • 07 Nov 2017 According to a CytomX Therapeutics media release, during the first half of 2018, an expansion cohort of the study at the recommended Phase 2 dose is expected to begin enrolling patients to evaluate CX-072 as monotherapy in a tumor type with known sensitivity to PD-L1 and/or PD-1 inhibitors (Part D).
    • 07 Nov 2017 According to a CytomX Therapeutics media release, patient enrollment has been initiated in all dose escalation arms of this trial.
    • 12 Sep 2017 Trial design of the study presented at the 42nd European Society for Medical Oncology Congress.
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