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A Phase 1/2 Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination With Gemcitabine Plus Cisplatin or Gemcitabine Alone in Subjects With Advanced Cancer

Trial Profile

A Phase 1/2 Trial of Oral SRA737 (a Chk1 Inhibitor) Given in Combination With Gemcitabine Plus Cisplatin or Gemcitabine Alone in Subjects With Advanced Cancer

Status: Completed
Phase of Trial: Phase I/II

Latest Information Update: 26 Jun 2023

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At a glance

  • Drugs SRA 737 (Primary) ; Cisplatin; Gemcitabine
  • Indications Anal cancer; Bladder cancer; Cervical cancer; Colorectal cancer; Ovarian cancer; Pancreatic cancer; Rectal cancer; Small cell lung cancer; Soft tissue sarcoma; Solid tumours; Urogenital cancer
  • Focus Adverse reactions; First in man; Proof of concept
  • Sponsors Sierra Oncology
  • Most Recent Events

    • 15 Nov 2022 Results of safety profile, recommended phase 2 dose (RP2D), pharmacokinetics profile, and clinical activity of SRA737,published in the Clinical Cancer Research
    • 23 Sep 2020 Status changed from active, no longer recruiting to completed.
    • 22 May 2020 This trial has been completed in Austria according to European Clinical Trials Database record.
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