Trial Profile
DART: Dual Anti-CTLA-4 and Anti-PD-1 Blockade in Rare Tumors
Status:
Active, no longer recruiting
Phase of Trial:
Phase II
Latest Information Update: 17 Apr 2024
Price :
$35
*
At a glance
- Drugs Ipilimumab (Primary) ; Nivolumab (Primary)
- Indications Adenocarcinoma; Adenoid cystic carcinoma; Adrenocortical carcinoma; Advanced breast cancer; Appendiceal cancer; Basal cell cancer; Carcinoma; Cervical cancer; Cholangiocarcinoma; Chordoma; Choriocarcinoma; Colon cancer; Colorectal cancer; Endometrial cancer; Extramammary Paget disease; Fibroma; Gallbladder cancer; Gastric cancer; Gastrointestinal cancer; Gastrointestinal stromal tumours; Gestational trophoblastic disease; Giant cell tumours; Haemangiosarcoma; Head and neck cancer; Laryngeal cancer; Lung cancer; Nerve sheath neoplasms; Neuroblastoma; Neuroendocrine tumours; Oesophageal cancer; Ovarian cancer; Pancreatic cancer; Paraganglioma; Parathyroid cancer; Pelvic cancer; Peritoneal cancer; Perivascular epithelioid cell tumours; Phaeochromocytoma; Pharyngeal neoplasms; Pituitary cancer; Prostate cancer; Rectal cancer; Renal cell carcinoma; Salivary gland cancer; Sarcoma; Seminoma; Solid tumours; Squamous cell cancer; Teratoma; Thyroid cancer; Tracheobronchial cancer; Trophoblastic tumour; Urogenital cancer; Vulvovaginal cancer
- Focus Therapeutic Use
- Acronyms DART
- 13 Dec 2023 Planned End Date changed from 31 Oct 2024 to 1 May 2026.
- 13 Dec 2023 Planned primary completion date changed from 31 Oct 2024 to 1 May 2026.
- 26 Oct 2023 Results (n=4) of the GTN cohort 47 assessing efficacy of Ipilimumab plus nivolumab in chemotherapy-refractory GTN, published in the Clinical Cancer Research