A Prospective, Randomized, International, Multicenter, Double-arm, Controlled, Open-label Study of Riociguat in Patients With Pulmonary Arterial Hypertension (PAH) Who Are on a Stable Dose of Phosphodiesterase-5 Inhibitors (PDE-5i) With or Without Endothelin Receptor Antagonist (ERA), But Not at Treatment Goal

Trial Profile

A Prospective, Randomized, International, Multicenter, Double-arm, Controlled, Open-label Study of Riociguat in Patients With Pulmonary Arterial Hypertension (PAH) Who Are on a Stable Dose of Phosphodiesterase-5 Inhibitors (PDE-5i) With or Without Endothelin Receptor Antagonist (ERA), But Not at Treatment Goal

Recruiting
Phase of Trial: Phase IV

Latest Information Update: 08 Oct 2017

At a glance

  • Drugs Riociguat (Primary) ; Sildenafil; Tadalafil
  • Indications Pulmonary arterial hypertension
  • Focus Therapeutic Use
  • Acronyms REPLACE
  • Sponsors Bayer
  • Most Recent Events

    • 16 Aug 2017 Planned End Date changed from 31 Jul 2018 to 30 Aug 2019.
    • 16 Aug 2017 Planned primary completion date changed from 1 Jul 2018 to 31 Jul 2019.
    • 10 Jun 2017 Biomarkers information updated
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