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A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)

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Trial Profile

A Single-Cohort, Phase 2 Study of Ruxolitinib in Combination With Corticosteroids for the Treatment of Steroid-Refractory Acute Graft-Versus-Host Disease (REACH-1)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 21 Jan 2022

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At a glance

  • Drugs Methylprednisolone (Primary) ; Prednisolone (Primary) ; Ruxolitinib (Primary)
  • Indications Graft-versus-host disease
  • Focus Registrational; Therapeutic Use
  • Acronyms REACH-1
  • Sponsors Incyte Corporation

    • Most Recent Events

    • 14 Dec 2021 Results of AREG as a monitoring biomarker in our larger uhCG/EGF treated cohort and validate them in an independent cohort of patients with steroid-refractory aGVHD receiving ruxolitinib as second-line therapy in the REACH1 study presented at the 63rd American Society of Hematology Annual Meeting and Exposition
    • 05 Aug 2020 Results published in the Blood
    • 29 Jul 2020 Status changed from active, no longer recruiting to completed.
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