Drug-drug interaction study with the cocktail administration of semi-pharmacological dose of multiple drugs to determine the quantitative contribution of OATPs and CYP3A4 to the clearance of the substrate drugs of both OATPs and CYP3A4.
Phase of Trial: Phase I
Latest Information Update: 15 Nov 2016
At a glance
- Drugs Bosentan (Primary) ; Clarithromycin (Primary) ; Darunavir (Primary) ; Itraconazole (Primary) ; Midazolam (Primary) ; Repaglinide (Primary) ; Rifampicin (Primary) ; Simeprevir (Primary)
- Indications Hepatitis C
- Focus Pharmacokinetics
- 15 Nov 2016 New trial record