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A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (Anti-LAG-3 mAb) Administered Alone or in Combination With REGN2810 (Anti-PD-1 mAb) in Patients With Advanced Malignancies

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Trial Profile

A Phase 1, Open-Label, Dose-Escalation and Cohort Expansion First-in-Human Study of the Safety, Tolerability, Activity and Pharmacokinetics of REGN3767 (Anti-LAG-3 mAb) Administered Alone or in Combination With REGN2810 (Anti-PD-1 mAb) in Patients With Advanced Malignancies

Status: Active, no longer recruiting
Phase of Trial: Phase I

Latest Information Update: 06 Mar 2024

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At a glance

  • Drugs Cemiplimab (Primary) ; Fianlimab (Primary)
  • Indications Cancer; Lymphoma; Malignant melanoma
  • Focus Adverse reactions; First in man; Pharmacokinetics; Therapeutic Use
  • Sponsors Regeneron Pharmaceuticals

    • Most Recent Events

    • 27 Jan 2024 Results (n=15; data cutoff date: as of 01 Nov 2022) reporting safety and clinical activity data from cohort 3 and 4 presented at the 2024 Genitourinary Cancers Symposium
    • 29 Nov 2023 Planned End Date changed from 27 Jan 2025 to 14 Dec 2024.
    • 29 Nov 2023 Planned primary completion date changed from 27 Jan 2025 to 14 Dec 2024.
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