Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy After Exposure to Only Pre-erythrocytic Stages of Plasmodium Falciparum

Trial Profile

Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Dose Escalation Trial to Determine Safety and Development of Protective Efficacy After Exposure to Only Pre-erythrocytic Stages of Plasmodium Falciparum

Recruiting
Phase of Trial: Phase I

Latest Information Update: 27 Jul 2017

At a glance

  • Drugs Malaria vaccine live attenuated-Sanaria (Primary) ; Pyrimethamine (Primary) ; Chloroquine diphosphate
  • Indications Malaria
  • Focus Adverse reactions; Therapeutic Use
  • Most Recent Events

    • 20 Jul 2017 Planned number of patients changed from 200 to 230.
    • 23 Mar 2017 New trial record
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