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A Phase 2, Open Label Study of Rucaparib in Patients With Advanced Pancreatic Cancer and a Known Deleterious Germline or Somatic BRCA or PALB2 Mutation

Trial Profile

A Phase 2, Open Label Study of Rucaparib in Patients With Advanced Pancreatic Cancer and a Known Deleterious Germline or Somatic BRCA or PALB2 Mutation

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 27 Feb 2024

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At a glance

  • Drugs Rucaparib (Primary)
  • Indications Adenocarcinoma; Liver cancer; Lung cancer; Pancreatic cancer; Peritoneal cancer; Squamous cell cancer
  • Focus Adverse reactions; Therapeutic Use
  • Most Recent Events

    • 20 Jan 2024 Results for four year survival update, presented at the 2024 Gastrointestinal Cancers Symposium
    • 27 Sep 2023 Status changed from active, no longer recruiting to discontinued.
    • 24 Jul 2023 Results (n=42) assessing Clinical Implications of Reversions in Patients with Advanced Pancreatic Cancer and Pathogenic Variants in BRCA1, BRCA2, or PALB2 After Progression on Rucaparib published in the Clinical Cancer Research
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