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A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-4482 for the Prevention of COVID-19 (Laboratory-confirmed SARS-CoV-2 Infection With Symptoms) in Adults Residing With a Person With COVID-19

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Trial Profile

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-4482 for the Prevention of COVID-19 (Laboratory-confirmed SARS-CoV-2 Infection With Symptoms) in Adults Residing With a Person With COVID-19

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 13 Feb 2024

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At a glance

  • Drugs Molnupiravir (Primary)
  • Indications COVID 2019 infections
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms MOVe-AHEAD
  • Sponsors Merck Sharp & Dohme; Merck Sharp & Dohme Corp.

    • Most Recent Events

    • 08 Sep 2023 Results published in the Journal of Infection
    • 21 Feb 2023 According to a Merck & Co media release, the company intends to submit full results from this study for presentation at a scientific meeting or for publication.
    • 21 Feb 2023 Primary endpoint (Percentage of participants who have undetectable SARS-CoV-2 in baseline nasopharyngeal (NP) swabs and develop COVID-19 (laboratory-confirmed SARS-CoV-2 infection with symptoms) through Day 14 [ Time Frame: Up to Day 14 ]) has not been met, according to a Merck & Co media release.
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