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Drug Profile


Alternative Names: Batenac®; Befral®; Cerate®; Mibefradil dihydrochloride; Posicor®; Quota®; RO 40-5967; Taxben®

Latest Information Update: 14 Aug 2019

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At a glance

  • Originator Roche
  • Developer Cavion
  • Class Antihypertensives; Benzimidazoles; Ischaemic heart disorder therapies; Small molecules; Tetrahydronaphthalenes; Vasodilators
  • Mechanism of Action Cell division modulators; DNA repair inhibitors; T type calcium channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pancreatic cancer; Ovarian cancer; Glioblastoma
  • New Molecular Entity Yes

Highest Development Phases

  • Market Withdrawal Angina pectoris; Hypertension
  • No development reported Glioblastoma; Glioma; Ovarian cancer; Pancreatic cancer; Solid tumours
  • Discontinued Arrhythmias; Heart failure

Most Recent Events

  • 12 Aug 2019 Cavion has been acquired by Jazz Pharmaceuticals plc
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Glioblastoma(Late-stage disease, Recurrent, Second-line therapy or greater) in USA (PO)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in Glioma(Combination therapy, Recurrent, Second-line therapy or greater) in USA (PO, Tablet)
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