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Pentostatin

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Drug Profile

Pentostatin

Alternative Names: 2'-Deoxycoformycin; CI 825; Coforin; DCF; Deoxycoformycin; Nipent; Nipentin; NSC 218321; Oncopent; PD 81565; YK 176

Latest Information Update: 16 Dec 2021

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At a glance

  • Originator National Cancer Institute (USA); Pfizer
  • Developer Hospira; National Cancer Institute (USA); Pfizer
  • Class Antineoplastics; Deoxyribonucleosides; Pyrimidine nucleosides; Small molecules
  • Mechanism of Action Adenosine deaminase inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T-cell lymphoma; Chronic lymphocytic leukaemia; Hairy cell leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Hairy cell leukaemia
  • No development reported Cutaneous T-cell lymphoma
  • Discontinued Graft-versus-host disease; Non-Hodgkin's lymphoma; Rheumatoid arthritis

Most Recent Events

  • 03 Sep 2015 Hospira has been acquired by Pfizer
  • 11 Oct 2013 Astex Pharmaceuticals has been acquired by Otsuka Pharmaceutical
  • 10 Aug 2010 Pentostatin is still in phase III trials for Chronic lymphocytic leukaemia

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