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Dexrazoxane - TopoTarget

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Drug Profile

Dexrazoxane - TopoTarget

Alternative Names: ADR 529; Cardioxane; Dexrazoxane hydrochloride; ICRF 187; KDX-0811; NSC 169780; Savene; Topotect; Totect

Latest Information Update: 27 Apr 2024

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At a glance

  • Originator TopoTarget
  • Developer Clinigen; Cumberland Pharmaceuticals; Kissei Pharmaceutical; TopoTarget; Valerio Therapeutics
  • Class Adjunct therapies; Chemoprotectants; Piperazines; Small molecules
  • Mechanism of Action Iron chelating agents; Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chemotherapy-induced damage
  • New Molecular Entity No
  • Available For Licensing Yes

Highest Development Phases

  • Marketed Cardiomyopathies; Chemotherapy-induced damage
  • Discontinued Brain cancer

Most Recent Events

  • 23 Apr 2024 Endo International has been acquired and merged into Endo, Inc.
  • 18 Aug 2023 CNX Therapeutics acquires Dexrazoxane from Clinigen
  • 10 Nov 2020 Registered for Cardiomyopathies in USA (IV)

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