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Topotecan - GlaxoSmithKline

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Drug Profile

Topotecan - GlaxoSmithKline

Alternative Names: Hycamptamine; Hycamtin; NK-211; Nogitecan; NSC 609699; SKF 104864; SKF S-104864-A; Topotecan HCl; Topotecan hydrochloride

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator GlaxoSmithKline
  • Developer GSK; Merck Pharmaceuticals UK; Nippon Kayaku; Novartis; SCRI Development Innovations
  • Class Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cervical cancer; Ovarian cancer; Small cell lung cancer
  • Discontinued Brain metastases

Most Recent Events

  • 23 Jun 2022 Novartis plans a phase I/II trial for Solid tumours (Combination therapy, Second-line therapy or greater) in August 2022 (NCT05429502)
  • 24 Aug 2021 Novartis Pharmaceuticals terminates a phase Ib/II study in Small-cell lung cancer and Ovarian cancer (Second-line therapy or greater, Combination therapy) in USA (PO)(NCT02649673)
  • 10 Jul 2019 Discontinued - Phase-III for Brain metastases (Metastatic disease) in Hungary, Poland, Russia, Canada, Slovakia, USA (PO)

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