Topotecan

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Drug Profile

Topotecan

Alternative Names: Hycamtin; NK-211; Nogitecan; NSC 609699; SKF 104864; Topotecan hydrochloride

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator GlaxoSmithKline
  • Developer Nippon Kayaku; Novartis; SCRI Development Innovations
  • Class Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cervical cancer; Ovarian cancer; Small cell lung cancer
  • Phase III Brain cancer

Most Recent Events

  • 18 Feb 2016 Investigation in Small cell lung cancer (Combination therapy) in USA (PO)
  • 18 Feb 2016 Phase-I/II clinical trials in Ovarian cancer (Combination therapy) in USA (PO)
  • 02 Mar 2015 Novartis acquires Topotecan from GlaxoSmithKline
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