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Topotecan - GlaxoSmithKline

Drug Profile

Topotecan - GlaxoSmithKline

Alternative Names: Hycamtin; NK-211; Nogitecan; NSC 609699; SKF 104864; Topotecan hydrochloride

Latest Information Update: 10 Jul 2019

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At a glance

  • Originator GlaxoSmithKline
  • Developer GlaxoSmithKline; Merck Pharmaceuticals UK; Nippon Kayaku; Novartis; SCRI Development Innovations
  • Class Antineoplastics; Camptothecins; Small molecules
  • Mechanism of Action DNA topoisomerase I inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cervical cancer; Ovarian cancer; Small cell lung cancer
  • Discontinued Brain metastases

Most Recent Events

  • 10 Jul 2019 Discontinued - Phase-III for Brain metastases (Metastatic disease) in Hungary, Poland, Russia, Canada, Slovakia, USA (PO)
  • 08 Aug 2017 Launched for Ovarian cancer in Russia, Ukraine, China, Venezuela, Norway, Israel, Malaysia, Denmark, Turkey, Hong Kong (IV) before August 2017 (IV) (Martindale)
  • 17 May 2016 Launched for Small cell lung cancer (Second- line therapy or later) in Russia, Ukraine, China, Norway, Israel, Switzerland, Hungary, Malaysia, France, Denmark, Turkey, Philippines, Hong Kong, South Africa, Czech Republic, Spain, Brazil, Sweden, Canada, Austria, Argentina, USA, United Kingdom, Chile, Belgium, Germany, Portugal, Australia, New Zealand, Italy, Finland, Greece, Poland, Netherlands, Ireland, Thailand, Singapore before May 2016 (IV) (Martindale)
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