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UCN 01

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Drug Profile

UCN 01

Alternative Names: 7-Hydroxystaurosporine; KRX-0601; KW-2401; NSC-638850; UCN-01; UCN-02

Latest Information Update: 22 May 2018

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At a glance

  • Originator Kyowa Hakko
  • Class Antineoplastics
  • Mechanism of Action 3-phosphoinositide-dependent protein kinase 1 inhibitors; Checkpoint kinase 1 inhibitors; Phosphotransferase inhibitors; Protein kinase C inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Discontinued Acute myeloid leukaemia; Cancer; Lymphoma; Malignant melanoma; Myelodysplastic syndromes; Ovarian cancer; Pancreatic cancer; Small cell lung cancer; Solid tumours

Most Recent Events

  • 22 May 2018 NCT00003289 - tagged source and CTP in KDM
  • 04 Apr 2008 Discontinued - Phase-I for Acute myeloid leukaemia in USA (IV-infusion)
  • 04 Apr 2008 Discontinued - Phase-I for Myelodysplastic syndromes in USA (IV-infusion)

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