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Decitabine - Janssen-Cilag/Otsuka Pharmaceutical

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Drug Profile

Decitabine - Janssen-Cilag/Otsuka Pharmaceutical

Alternative Names: 127716; 2'-deoxy-5-azacytidine; 2353-33-5; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 5-aza-2'-deoxycytidine; DAC; Dacogen; Decitabine mesylate; Deoxycytidine; Dezocitidine; E-7373; NSC-127716

Latest Information Update: 28 Nov 2023

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At a glance

  • Originator Indiana University; SuperGen
  • Developer Eisai Co Ltd; European Organisation for Research and Treatment of Cancer; Groupe Francophone des Myelodysplasies; HOVON Foundation; Italian Group for Haematological Diseases; Janssen-Cilag; Johnson & Johnson Innovative Medicine; M. D. Anderson Cancer Center; Novartis; Otsuka Pharmaceutical; Sidney Kimmel Cancer Center; Xian-Janssen
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action Antimetabolites; DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Myelodysplastic syndromes
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute myeloid leukaemia; Chronic myeloid leukaemia; Myelodysplastic syndromes
  • Phase III Chronic myelomonocytic leukaemia
  • Phase I/II Malignant melanoma; Ovarian cancer
  • No development reported Myelofibrosis; Solid tumours
  • Discontinued Colorectal cancer

Most Recent Events

  • 28 Nov 2023 No recent reports of development identified for phase-I development in Myelofibrosis(Combination therapy, Treatment-experienced) in Spain (IV)
  • 01 Oct 2023 Janssen Pharmaceuticals is now called Johnson & Johnson Innovative Medicine (Janssen Pharmaceuticals website, October 2023)
  • 09 Jan 2023 Efficacy data from a phase III trial in Acute myeloid leukaemia presented at the 64th American Society of Hematology Annual Meeting and Exposition(ASH-Hem-2023)

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