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Decitabine - Janssen-Cilag/Otsuka Pharmaceutical

Drug Profile

Decitabine - Janssen-Cilag/Otsuka Pharmaceutical

Alternative Names: 127716; 2'-deoxy-5-azacytidine; 2353-33-5; 4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one; 5-aza-2'-deoxycytidine; DAC; Dacogen; Decitabine mesylate; Deoxycytidine; Dezocitidine; E 7373; NSC-127716

Latest Information Update: 29 Nov 2018

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At a glance

  • Originator Indiana University; SuperGen
  • Developer Eisai Co Ltd; HOVON Foundation; Janssen-Cilag; M. D. Anderson Cancer Center; Otsuka Pharmaceutical; Sidney Kimmel Cancer Center; Xian-Janssen
  • Class Antineoplastics; Aza compounds; Deoxyribonucleosides; Pyrimidine nucleosides; Ribonucleosides; Small molecules
  • Mechanism of Action DNA methylation inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Acute myeloid leukaemia; Sickle cell anaemia; Myelodysplastic syndromes; Chronic myeloid leukaemia
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute myeloid leukaemia; Chronic myeloid leukaemia; Myelodysplastic syndromes
  • Phase I/II Malignant melanoma; Ovarian cancer
  • Discontinued Colorectal cancer

Most Recent Events

  • 07 Nov 2018 Eisai terminates a phase I/II trial in Malignant melanoma (Late-stage disease, Metastatic disease, Inoperable/Unresectable, Second-line therapy or greater, Combination therapy) in USA due to toxicity and lack of efficacy (IV) (NCT00791271)
  • 24 Jun 2018 Biomarkers information updated
  • 29 Nov 2017 Discontinued - Phase-I/II for Colorectal cancer (Inoperable/Unresectable, Late-stage disease, Metastatic disease) in Belgium (IV)
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