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Hypericin sodium - Soligenix

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Drug Profile

Hypericin sodium - Soligenix

Alternative Names: HyBryte; Hypericin - Soligenix; SGX-301; SGX-302; Synthetic hypericin - Soligenix; VIMRxyn

Latest Information Update: 17 Feb 2026

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At a glance

  • Originator New York University; Weizmann Institute of Science
  • Developer Soligenix
  • Class Anthraquinones; Anti-inflammatories; Antidepressants; Antineoplastics; Antipsoriatics; Antivirals; Cytostatics; Perylenes; Polycyclic compounds; Radiation-sensitising agents; Skin disorder therapies; Small molecules
  • Mechanism of Action Cell death stimulants; HSP90 heat-shock protein inhibitors; Photosensitisers; Protein kinase C inhibitors; Singlet oxygen stimulants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cutaneous T-cell lymphoma; T-cell lymphoma; Glioblastoma
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase III Cutaneous T-cell lymphoma
  • Phase II Mycosis fungoides; Psoriasis
  • Discontinued Glioma; Hepatitis C; HIV infections; Hyperhidrosis; Kaposi's sarcoma

Most Recent Events

  • 12 Feb 2026 Soligenix announces intention to pursue marketing authorizations for Hypericin sodium worldwide
  • 22 Dec 2025 Soligenix completes a phase II clinical trials in Mycosis fungoides in USA (Topical) (NCT05872854)
  • 17 Dec 2025 Efficacy and adverse events data from a phase IIa trial in Psoriasis released by Soligenix

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