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Drug Profile


Alternative Names: Forvade®; GS 504; HPMPC; Vistide

Latest Information Update: 04 Nov 2017

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At a glance

  • Originator Institute of Organic Chemistry and Biochemistry (Prague); Rega Institute for Medical Research
  • Developer Gilead Sciences; Institute of Organic Chemistry and Biochemistry (Prague); Pfizer; Rega Institute for Medical Research; University of Texas M. D. Anderson Cancer Center
  • Class Antivirals; Phosphonic acids; Pyrimidinones; Small molecules
  • Mechanism of Action DNA-directed DNA polymerase inhibitors; Immunomodulators
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Cytomegalovirus retinitis
  • No development reported Cystitis
  • Discontinued Cancer; Herpes simplex virus infections; Human papillomavirus infections; Kaposi's sarcoma; Molluscum contagiosum; Polyomavirus infections; Rheumatic disorders; Viral infections

Most Recent Events

  • 04 Nov 2017 No recent reports of development identified for phase-I development in Cystitis in USA (Intravesicular, Liquid)
  • 01 Dec 2016 Gilead Sciences completes a phase I trial in Cystitis (in patients who have undergone haematopoietic stem cell transplant) in USA (Intravesicular) (NCT01816646)
  • 06 Sep 2013 Phase-I clinical trials in Cystitis (in patients who have undergone haematopoietic stem cell transplant) in USA (Intravesicular) (NCT01816646)
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