Acadesine

Drug Profile

Acadesine

Alternative Names: Acadra; AICA riboside; ARA 100; Arasine; ATH 001; GP 1 110; Protara; SCH 900395

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator AdvanCell; SICOR
  • Developer Advancell; Groupe Francophone des Myelodysplasies; Merck & Co; SICOR
  • Class Amides; Antineoplastics; Antiplatelets; Imidazoles; Ribonucleosides; Small molecules
  • Mechanism of Action Apoptosis stimulants; Platelet aggregation inhibitors; Purinergic P1 receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Chronic lymphocytic leukaemia
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • No development reported Chronic lymphocytic leukaemia; Mantle-cell lymphoma; Multiple myeloma; Myelodysplastic syndromes
  • Discontinued Asthma; Diabetes mellitus; Ischaemic heart disorders; Thrombosis

Most Recent Events

  • 07 Nov 2016 AdvanCell terminates a phase I/II trial for Myelodysplastic syndromes (Treatment-resistant, Recurrent) in France prior to November 2016 (NCT01813838)
  • 16 Sep 2015 No recent reports on development identified - Phase-I/II for Chronic lymphocytic leukaemia (Second-line therapy or greater) in Belgium, France and Spain (IV)
  • 13 Nov 2011 Preclinical pharmacodynamics data presented at the 23rd AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics (AACR-NCI-EORTC-2011)
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