Rintatolimod - Hemispherx Biopharma

Drug Profile

Rintatolimod - Hemispherx Biopharma

Alternative Names: Ampligen; Atvogen; Mismatched double-stranded RNA - Hemispherx Biopharma; Poly I:Poly C12U; Poly I:polyC12U; poly(I) poly(C12,U); Rintamod; Vaccine-adjuvant-poly-I-polyC12U; Vaccine-adjuvant-rintatolimod

Latest Information Update: 29 Oct 2018

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At a glance

  • Originator Hemispherx Biopharma
  • Developer Hemispherx Biopharma; National Cancer Institute (USA); Roswell Park Cancer Institute; United States Army Medical Research Institute of Infectious Diseases; University of Pittsburgh
  • Class Adjuvants; Antineoplastics; Antivirals; Oligonucleotides
  • Mechanism of Action HIV replication inhibitors; Interferon stimulants; Ribonuclease stimulants; RNA synthesis inhibitors; Toll-like receptor 3 agonists; VP35 protein inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Renal cell carcinoma; Ebola virus infections; HIV infections; Chronic fatigue syndrome; Malignant melanoma
  • New Molecular Entity Yes

Highest Development Phases

  • Registered Chronic fatigue syndrome
  • Phase II Colorectal cancer
  • Phase I/II Breast cancer; Influenza virus infections; Ovarian cancer; Peritoneal cancer
  • Clinical Phase Unknown Pancreatic cancer
  • Preclinical Ebola virus infections; West Nile virus infections; Zika virus infection
  • Research Coronavirus infections; Influenza A virus infections
  • Suspended HIV infections
  • No development reported Hepatitis B; Malignant melanoma; Renal cell carcinoma
  • Discontinued Smallpox; Western equine encephalitis virus infections

Most Recent Events

  • 22 Oct 2018 Hemispherx Biopharma and the University of Nebraska Medical Center plans a clinical trial for Pancreatic cancer in USA (IV)
  • 10 Oct 2018 Hemispherx Biopharma and Roswell Park Comprehensive Cancer Center plans phase IIa trial for advanced urothelial cancer, renal cell carcinoma and Melanoma (Second line therapy or greater, Combination therapy) in USA
  • 13 Aug 2018 Hemispherx Biopharma plans a phase I and phase II trials for Cancer in combination with checkpoint inhibitors
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