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Cladribine - Johnson and Johnson/Merck Serono

Drug Profile

Cladribine - Johnson and Johnson/Merck Serono

Alternative Names: 2-CdA; 2-Chloro-2-deoxyadenosine; 2-Chlorodeoxyadenosine; 2CDA; Chlorodeoxyadenosine; Intocel; Leustat; Leustatin; Mavenclad; Movectro; Mylinax; RWJ 26251

Latest Information Update: 04 Apr 2019

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At a glance

  • Originator Scripps Clinic
  • Developer EMD Serono; Janssen-Cilag; Merck Serono; Orphan Australia
  • Class Antineoplastics; Antipsoriatics; Deoxyadenosines; Purine nucleosides; Ribonucleosides; Skin disorder therapies; Small molecules
  • Mechanism of Action Immunosuppressants
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple sclerosis; Leukaemia; Lymphoma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Chronic lymphocytic leukaemia; Hairy cell leukaemia; Leukaemia; Lymphoma; Multiple sclerosis
  • No development reported Psoriasis; Transplant rejection

Most Recent Events

  • 29 Mar 2019 Registered for Multiple sclerosis in USA (PO)
  • 25 Mar 2019 Registered for Multiple sclerosis in Switzerland (PO)
  • 17 Jan 2019 Merck KGaA initiates a phase I trial for Multiple Sclerosis in Germany and Poland (PO) (NCT03745144)
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