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At a glance
Originator
Medical University of South Carolina; Oncovir
Developer
Abramson Cancer Center of the University of Pennsylvania; Augusta University; Bristol-Myers Squibb; Celldex Therapeutics Inc; Icahn School of Medicine at Mount Sinai; Immatics N.V.; Ludwig Institute for Cancer Research; Medical University of South Carolina; Memorial Sloan-Kettering Cancer Center; Merck Sharp & Dohme; National Cancer Institute (USA); New York University School of Medicine; OncoQuest; Oncovir; Quest PharmaTech; Roswell Park Cancer Institute; Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University Hospitals of Geneva; University of Calgary; University of California, San Diego; University of Pittsburgh; Washington University School of Medicine
Class
Adjuvants; Antineoplastics; Antivirals; Biopolymers; Oligonucleotides
Mechanism of Action
2',5' oligoadenylate synthetase modulators; DDX58 protein modulators; IFIH1 protein modulators; Immunomodulators; Natural killer cell stimulants; Natural killer T cell stimulants; Proto oncogene protein c rel modulators; Proto oncogene protein c-ret modulators; Toll-like receptor 3 agonists
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Flavivirus infections; Orthopoxvirus infections; Brain cancer
New Molecular Entity
No
Highest Development Phases
Phase II
Head and neck cancer; Malignant melanoma; Ovarian cancer; Sarcoma; Skin cancer; Solid tumours
Phase I/II
B-cell lymphoma; Breast cancer; Colorectal cancer; Fallopian tube cancer; Glioblastoma; HIV infections; Non-Hodgkin's lymphoma; Peritoneal cancer
Phase I
COVID 2019 infections; Liver cancer; Mesothelioma; Pancreatic cancer; Prostate cancer
No development reported
Acute myeloid leukaemia; Anaplastic astrocytoma; Chronic myelomonocytic leukaemia; Cytomegalovirus infections; Glioma; Influenza virus infections; Myelodysplastic syndromes; Smallpox
Most Recent Events
28 Jul 2022
No recent reports of development identified for phase-I development in Prostate-cancer(Combination therapy, Hormone refractory, Metastatic disease, Second-line therapy or greater) in USA (IM, Injection)
06 May 2022
Icahn School of Medicine at Mount Sinai and Oncovir, completes a phase I trial in Prostate cancer (Neoadjuvant therapy) in USA (IM) (NCT03262103)
06 May 2022
Icahn School of Medicine at Mount Sinai and Oncovir, completes a phase I trial in Prostate cancer (Neoadjuvant therapy) in USA (Intratumoural) (NCT03262103)
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