Drug Profile


Alternative Names: D-1694; ICI-D1694; Tomudex; ZD 1694; ZN-D1694

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator The Institute of Cancer Research
  • Developer AstraZeneca; Centre Georges Francois Leclerc; Hospira; National Cancer Institute (France)
  • Class Antineoplastics; Quinazolines; Small molecules; Thiophenes
  • Mechanism of Action Thymidylate synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Colorectal cancer; Mesothelioma

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 18 Apr 2018 Centre Georges Francois Leclerc completes a phase II trial in Colorectal cancer (Combination therapy, Second-line therapy or greater, Metastatic disease) in France (Intra-arterial) (NCT01348412)
  • 21 Jun 2017 Phase-II development for Colorectal cancer in patients with unresectable liver metastases is ongoing in France (Intra-arterial) (NCT01348412)
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