Letrozole - Novartis

Drug Profile

Letrozole - Novartis

Alternative Names: CGP 20267; CGS 20267; Femara

Latest Information Update: 24 Mar 2018

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At a glance

  • Originator Novartis
  • Developer M. D. Anderson Cancer Center; National Cancer Institute (USA); Novartis; University of Colorado at Denver
  • Class Antineoplastics; Nitriles; Small molecules; Triazoles
  • Mechanism of Action Aromatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II Endometrial cancer; Fallopian tube cancer; Leiomyosarcoma; Ovarian cancer; Peritoneal cancer
  • Discontinued Delayed puberty; Endometriosis; Female infertility

Most Recent Events

  • 21 Nov 2017 Phase-I/II clinical trials in Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in USA (PO) (NCT03054363)
  • 18 Aug 2017 Phase-II clinical trials in Endometrial cancer (Combination therapy, Second-line therapy or greater, Late-stage disease, Recurrent) in USA (PO) (NCT03008408)
  • 01 Jul 2017 Novartis and M.D. Anderson Cancer Center terminates a phase II trial in Leiomyosarcoma (Newly diagnosed, Adjuvant therapy) in USA due to low accrual (NCT00414076)
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