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Letrozole - Novartis

Drug Profile

Letrozole - Novartis

Alternative Names: CGP 20267; CGS 20267; Femara

Latest Information Update: 08 Jun 2019

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At a glance

  • Originator Novartis
  • Developer Eli Lilly and Company; Gynecologic Oncology Group; International Breast Cancer Study Group; M. D. Anderson Cancer Center; National Cancer Institute (USA); Novartis; Roche; University of Colorado at Denver
  • Class Antineoplastics; Nitriles; Small molecules; Triazoles
  • Mechanism of Action Aromatase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer
  • Phase II Endometrial cancer; Fallopian tube cancer; Leiomyosarcoma; Ovarian cancer; Peritoneal cancer
  • Discontinued Delayed puberty; Endometriosis; Female infertility

Most Recent Events

  • 31 May 2019 Interim efficacy and adverse events data from the phase-IIIb CompLEEment-1 trial in Breast cancer presented at the 55th Annual Meeting of the American Society of Clinical Oncology (ASCO-2019)
  • 25 Feb 2019 Novartis Pharmaceuticals initiates a phase II RIGHT Choice trial for Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Inoperable/Unresectable) in Malaysia and Taiwan (PO) (NCT03839823)
  • 24 Dec 2018 Phase-II clinical trials in Endometrial cancer (Second-line therapy or greater, Recurrent, Combination therapy) in USA (PO) (NCT03675893)
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