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Levosimendan - AbbVie/Tenax Therapeutics

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Drug Profile

Levosimendan - AbbVie/Tenax Therapeutics

Alternative Names: Daxim; ODM 109; OR-1259; Simdax; TNX-101; TNX-102 - Tenax Therapeutics; TNX-103; TNX102

Latest Information Update: 23 Mar 2026

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At a glance

  • Originator Orion
  • Developer Abbott Laboratories; AbbVie; Imperial College of Science, Technology and Medicine; Orion; Tenax Therapeutics; Yooyoung Pharmaceutical
  • Class Antiarrhythmics; Cardiotonics; Cardiovascular therapies; Hydrazones; Nitriles; Pyridazines; Small molecules; Vasodilators
  • Mechanism of Action Calcium binding protein modulators; Calcium-sensitising phosphodiesterase inhibitors; Potassium channel agonists; Type 3 cyclic nucleotide phosphodiesterase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Amyotrophic lateral sclerosis
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute heart failure
  • Phase III Amyotrophic lateral sclerosis; Chronic heart failure; Low cardiac output; Pulmonary hypertension
  • Discontinued Myocardial infarction; Septic shock; Stroke; Transient ischaemic attacks

Most Recent Events

  • 10 Mar 2026 Tenax Therapeutics completes enrolment in the phase III LEVEL trial for Pulmonary hypertension in USA and Canada
  • 27 Feb 2026 Phase-III clinical trials in Pulmonary hypertension (Treatment-experienced, In children, In adults, In the elderly) in USA (PO) (NCT07436689)
  • 01 Jan 2026 Tenax Therapeutics receives notice of allowance for Levosimendan in USA (SC)

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