Drug Profile

Levosimendan - AbbVie/Tenax Therapeutics

Alternative Names: Daxim; ODM 109; OR-1259; Simdax; TNX-101; TNX-102 - Tenax Therapeutics; TNX-103; TNX102

Latest Information Update: 02 Sep 2026

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At a glance

Originator Orion
Developer Abbott Laboratories; AbbVie; Imperial College of Science, Technology and Medicine; Orion; Tenax Therapeutics; Yooyoung Pharmaceutical
Class Antiarrhythmics; Cardiotonics; Cardiovascular therapies; Hydrazones; Nitriles; Pyridazines; Small molecules; Vasodilators
Mechanism of Action Calcium-binding protein modulators; Calcium-sensitising phosphodiesterase inhibitors; Potassium channel agonists; Type 3 cyclic nucleotide phosphodiesterase inhibitors

Orphan Drug Status

Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

Yes - Amyotrophic lateral sclerosis
New Molecular Entity Yes

Marketed Acute heart failure
Phase III Amyotrophic lateral sclerosis; Chronic heart failure; Low cardiac output; Pulmonary hypertension
Discontinued Myocardial infarction; Septic shock; Stroke; Transient ischaemic attacks

29 Aug 2026 Efficacy and adverse events data from phase III clinical trials in Pulmonary hypertension released by Tenax Therapeutics
10 Aug 2026 Efficacy and adverse event data from the phase III LEVEL trial in Pulmonary hypertension released by Orion Pharma
10 Aug 2026 Updated efficacy, pharmacodynamics and adverse event data from the phase III LEVEL trial in Pulmonary hypertension released by Tenax Therapeutics

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