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Ubenimex - Eiger Biopharmaceuticals/Nippon Kayaku

Drug Profile

Ubenimex - Eiger Biopharmaceuticals/Nippon Kayaku

Alternative Names: 1580RB; Bestatin; NK 421; Ubestatin

Latest Information Update: 28 Dec 2019

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At a glance

  • Originator Institute of Microbial Chemistry
  • Developer Eiger BioPharmaceuticals, Inc.; Nippon Kayaku
  • Class Antineoplastics; Branched-chain amino acids; Dipeptides; Essential amino acids; Small molecules
  • Mechanism of Action Aminopeptidase B inhibitors; Aminopeptidase inhibitors; Immunostimulants; Leukotriene A4 hydrolase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Pulmonary arterial hypertension
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute nonlymphocytic leukaemia
  • No development reported Inflammation
  • Discontinued HIV infections; Lymphoedema; Pulmonary arterial hypertension

Most Recent Events

  • 28 Dec 2019 No recent reports of development identified for preclinical development in Inflammation in USA (PO)
  • 28 Feb 2019 Eiger BioPharmaceuticals completes the ULTRA trial for Lymphoedema in Australia and USA (NCT02700529)
  • 01 Aug 2018 Eiger BioPharmaceuticals terminates the extension phase II LIBERTY2 trial for Pulmonary arterial hypertension in USA and Canada following the failure to demonstrate efficacy in EIG-UBX-001 trial (PO) (NCT02736149)
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