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Triciribine - Prescient Therapeutics

Drug Profile

Triciribine - Prescient Therapeutics

Alternative Names: API-2; NSC 154020; NSC 280594; PTX-200 - Prescient Therapeutics; TCN; TCN-P; Tricirbine phosphate monohydrate; VQD-002; VQD-002-ORAL

Latest Information Update: 02 Oct 2021

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At a glance

  • Originator University of South Florida
  • Developer Cahaba Pharmaceuticals; H. Lee Moffitt Cancer Center and Research Institute; Prescient Therapeutics; VioQuest Pharmaceuticals
  • Class Ribonucleosides; Small molecules
  • Mechanism of Action DNA synthesis inhibitors; Protein kinase inhibitors; Proto oncogene protein c-akt inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Multiple myeloma
  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Acute myeloid leukaemia; Breast cancer; Ovarian cancer
  • No development reported Haematological malignancies; Pancreatic cancer; Solid tumours
  • Discontinued Cancer; HIV infections

Most Recent Events

  • 17 Jun 2020 Prescient Therapeutics terminates a phase I/II trial in Breast cancer (Combination therapy, Late-stage disease, Metastatic disease, Second-line therapy or greater) in USA (IV) for failure to meet enrolment criteria in the phase II portion of the trial (NCT01697293)
  • 31 Dec 2019 Prescient Therapeutics terminated the phase I/II trial in Ovarian cancer (Combination therapy, Recurrent, Second-line therapy or greater) in USA due to change in strategic focus (IV) (NCT01690468)
  • 01 Sep 2016 Phase-I/II clinical trials in Acute myeloid leukaemia (Combination therapy, Second-line therapy or greater) in USA (IV) (NCT02930109)
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