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Tirapazamine

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Drug Profile

Tirapazamine

Alternative Names: NSC 130181; SR 259075; SR 4233; Tirazone; WIN 59075

Latest Information Update: 29 Nov 2017

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At a glance

  • Originator SRI International; Stanford Cancer Institute
  • Developer SRI International; Teclison
  • Class Antineoplastics; Radiation-sensitising agents; Reducing agents; Small molecules; Triazines
  • Mechanism of Action Type II DNA topoisomerase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Phase III Cervical cancer
  • Phase II Colorectal cancer; Liver cancer
  • Discontinued Glioma; Head and neck cancer; Malignant melanoma; Non-small cell lung cancer

Most Recent Events

  • 24 Jun 2018 Biomarkers information updated
  • 13 Nov 2017 Teclison initiates enrolment in a phase II trial for liver cancer in USA (IV) (NCT03145558)
  • 04 Nov 2017 No recent reports of development identified for phase-I development in liver cancer in Taiwan (IV, Infusion)
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