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Brimonidine - Allergan

Drug Profile

Brimonidine - Allergan

Alternative Names: AGN 190342; AGN 190342LF; Aiphagan Ophthalmic Solution 0.1%; Alphagan; Alphagan P; Alphagan Z; Brimonidine tartrate; DE 087; SNJ-2022; UK 1430 18; UK 14304

Latest Information Update: 05 Nov 2018

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At a glance

  • Originator Pfizer
  • Developer Allergan; Senju Pharmaceutical
  • Class Antiglaucomas; Antihypertensives; Imidazoles; Quinoxalines; Small molecules
  • Mechanism of Action Alpha 2 adrenergic receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Glaucoma; Ocular hypertension
  • Phase II Dry age-related macular degeneration
  • No development reported Retinal detachment; Retinitis pigmentosa
  • Discontinued Neurological disorders

Most Recent Events

  • 30 Oct 2018 Efficacy data from the phase II BEACON trial in Dry age-related macular degeneration released by Allergan
  • 30 Oct 2018 Allergan plans a phase III trial for brimonidine intravitreal implant in geographic atrophy due to age-related macular degeneration, in the second half of 2019
  • 31 Aug 2018 Brimonidine terminates phase II trials in Dry age-related macular degeneration in USA, Australia, France, Germany, Italy and United Kingdom (Intravitreous) (NCT02087085)
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