Drug Profile


Alternative Names: AGN 190342; AGN 190342LF; Aiphagan Ophthalmic Solution 0.1%; Alphagan; Alphagan P; Alphagan Z; Brimonidine tartrate; DE 087; SNJ-2022; UK 1430 18; UK 14304

Latest Information Update: 19 Sep 2018

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At a glance

  • Originator Pfizer
  • Developer Allergan; Senju Pharmaceutical
  • Class Antiglaucomas; Antihypertensives; Imidazoles; Quinoxalines; Small molecules
  • Mechanism of Action Alpha 2 adrenergic receptor agonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Glaucoma; Ocular hypertension
  • Phase II Dry age-related macular degeneration
  • No development reported Retinal detachment; Retinitis pigmentosa
  • Discontinued Neurological disorders

Most Recent Events

  • 31 Aug 2018 Brimonidine terminates phase II trials in Dry age-related macular degeneration in USA, Australia, France, Germany, Italy and United Kingdom (Intravitreous) (NCT02087085)
  • 28 Sep 2015 Senju Pharmaceutical and Kanto Central Hospital of the Mutual Aid Association of Public School Teachers complete an exploratory phase II trial in Glaucoma and Ocular hypertension (In adults, In the elderly) in Japan (Topical) (UMIN000019142)
  • 31 Aug 2015 Phase-II development is ongoing for Dry age-related macular degeneration in World (Implant)
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