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Sirolimus - Pfizer

Drug Profile

Sirolimus - Pfizer

Alternative Names: AY 22989; CYPHER; CYPHER SELECT PLus; NEVO; NPC-12; NPC-12G; NPC-12T; NSC 226080; NSC 606698; Rapalimus; Rapamune; Rapamycin

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Wyeth
  • Developer Boston Childrens Hospital; Cordis Corporation; Food and Drug Administration; Le Bonheur Children's Hospital; National Center for Advancing Translational Sciences; Nobelpharma; Pfizer; Wyeth
  • Class Anti-infectives; Antiepileptic drugs; Antifungals; Antineoplastics; Cardiovascular therapies; Lactones; Macrolides; Polyenes; Pyridines
  • Mechanism of Action B cell inhibitors; Immunosuppressants; MTOR protein inhibitors; T lymphocyte inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Fibroma
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Coronary artery restenosis; Lymphangioleiomyomatosis; Renal transplant rejection
  • Registered Fibroma
  • Phase II Kasabach-Merritt syndrome; Systemic lupus erythematosus
  • Discontinued Autosomal dominant polycystic kidney disease; Mycoses

Most Recent Events

  • 29 Jun 2018 Preregistration for Lymphangioleiomyomatosis in European Union (PO)
  • 29 Jun 2018 CHMP recommended change in terms of the MAA to include lymphangioleiomyomatosis in the European Union
  • 23 Mar 2018 Registered for Fibroma (In adolescents, In children, In the elderly, In adults) in Japan (Topical)
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