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Daclizumab - AbbVie/Biogen

Drug Profile

Daclizumab - AbbVie/Biogen

Alternative Names: BIIB-019; DAC HYP; Dacliximab; Daclizumab high-yield process; Daclizumab HYP; HAT antibody; Humanised anti-Tac antibody; R35; RO 247375; SMART anti-Tac antibody; Zenapax; Zinbryta

Latest Information Update: 20 Dec 2018

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At a glance

  • Originator PDL BioPharma
  • Developer AbbVie; Biogen; Dana-Farber Cancer Institute; National Cancer Institute (USA); PDL BioPharma
  • Class Antiasthmatics; Antihyperglycaemics; Monoclonal antibodies
  • Mechanism of Action Immunosuppressants; Interleukin 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Renal transplant rejection
  • Phase III Multiple sclerosis
  • Discontinued Asthma; Graft-versus-host disease; Haematological malignancies; Immune-mediated uveitis; Liver transplant rejection; Psoriasis; Tropical spastic paraparesis; Type 1 diabetes mellitus; Ulcerative colitis

Most Recent Events

  • 22 Nov 2018 Biogen and AbbVie terminates phaseIII trial in Multiple Sclerosis in Argentina, Australia, Brazil, Canada, Czech Republic, Denmark, England, Finland, France, Georgia, Germany, Greece, Hungary, India, Ireland, Israel, Italy, Mexico, Moldova, Multinational, Poland, Romania, Russia, Scotland, Senegal, Serbia, Spain, Sweden, Switzerland, Ukraine, United Kingdom, USA (NCT01797965)
  • 15 Sep 2018 Discontinued - Phase-III for Multiple sclerosis (Recurrent) in Puerto Rico (SC) (NCT02881567)
  • 15 Sep 2018 Biogen and AbbVie terminates the phase IIIb SUSTAIN trial for Multiple sclerosis in Germany, United Kingdom, USA, Canada, Italy, Puerto Rico due to Biogen's decision to withdraw Zinbryta from the market (NCT02881567)
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