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Ivabradine - Servier

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Drug Profile

Ivabradine - Servier

Alternative Names: AMG-998; Coralan; Coraxan; Corlanor; Corlentor; Ivabradine hydrochloride; LANCORA; ONO-1162; Procoralan; S-16257; S-16257-2; S-57

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Servier
  • Developer Amgen; Ono Pharmaceutical; Servier; University of California, San Diego
  • Class Benzazepines; Bradycardic agents; Heterocyclic bicyclo compounds; Ischaemic heart disorder therapies; Small molecules
  • Mechanism of Action Hyperpolarisation activated cation channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Angina pectoris; Chronic heart failure
  • Phase III Coronary artery disease; Tachycardia
  • Phase II Low cardiac output

Most Recent Events

  • 08 Aug 2022 Ono Pharmaceutical completed a phase-III clinical trial in Chronic heart failure in Japan (PO) (JapicCTI-153007)
  • 29 Jun 2021 Dana-Farber Cancer Institute and Amgen terminates a phase II trial in Chronic heart failure in USA (PO) as funding terminated (NCT03137537)
  • 06 Apr 2021 Dana-Farber Cancer Institute and Amgen suspends a phase II trial in Chronic heart failure in USA (PO) as funding terminated (NCT03137537)

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