Ivabradine - Servier

Drug Profile

Ivabradine - Servier

Alternative Names: AMG-998; Coralan; Coraxan; Corlanor; Corlentor; Ivabradine hydrochloride; LANCORA; ONO-1162; Procoralan; S-16257; S-16257-2; S-57

Latest Information Update: 13 Nov 2018

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At a glance

  • Originator Servier
  • Developer Amgen; Ono Pharmaceutical; Servier; University of California, San Diego
  • Class Benzazepines; Bradycardic agents; Heterocyclic bicyclo compounds; Ischaemic heart disorder therapies; Small molecules
  • Mechanism of Action Hyperpolarisation activated cation channel antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Angina pectoris; Chronic heart failure
  • Phase III Coronary artery disease; Tachycardia
  • Phase II Low cardiac output

Most Recent Events

  • 07 Aug 2018 Amgen plans a phase III trial for Heart transplant recipients in September 2018 (PO) (NCT03619187)
  • 27 Feb 2018 Dana-Farber Cancer Institute and Amgen initiates enrolment in a phase II trial for Chronic heart failure in USA (NCT03137537)
  • 31 Jul 2017 Servier terminates a phase-II trial in Healthy volunteers in United Kingdom (PO) (EudraCT2012-005627-32)
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