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Drug Profile


Alternative Names: EI 546; Elaspol; LY 544349; ONO 5046; ONO 5046 . Na; ONO 5406; ONO 5406 . Na

Latest Information Update: 05 Nov 2023

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At a glance

  • Originator Ono Pharmaceutical
  • Class Amino acids; Antiasthmatics; Antineoplastics; Antirheumatics; Sulfonamides
  • Mechanism of Action Leucocyte elastase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Acute lung injury
  • Discontinued Adult respiratory distress syndrome; Lung disorders; Lung transplant rejection; Non-small cell lung cancer; Pulmonary fibrosis; Respiratory insufficiency; Rheumatoid arthritis

Most Recent Events

  • 13 May 2010 Discontinued - Phase-II for Respiratory insufficiency in Japan (unspecified route)
  • 30 Oct 2009 Sivelestat is still in phase II trials for respiratory insufficiency in Japan
  • 20 Dec 2006 Launched for Acute lung injury in South Korea (IV)
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