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APX 3330

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Drug Profile

APX 3330

Alternative Names: APX-3330; E-3330

Latest Information Update: 21 Aug 2024

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At a glance

  • Originator Eisai Co Ltd
  • Developer Apexian Pharmaceuticals; Ocuphire Pharma
  • Class Anti-inflammatories; Antineoplastics; Antivirals; Eye disorder therapies; Hepatoprotectants; Neuroprotectants; Quinones; Small molecules
  • Mechanism of Action Angiogenesis inhibitors; APEX1 protein inhibitors; DNA-apurinic apyrimidinic site lyase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    No
  • New Molecular Entity Yes
  • Available For Licensing Yes

Highest Development Phases

  • Phase II Diabetic macular oedema; Diabetic retinopathy; Hepatitis B; Hepatitis C; Liver cirrhosis
  • Phase I Solid tumours
  • Preclinical Inflammatory bowel diseases; Pancreatic cancer
  • Discontinued Haematological malignancies; Liver disorders; Peripheral nervous system diseases

Most Recent Events

  • 13 Aug 2024 Ocuphire Pharma files special protocol assessment (SPA) to US FDA for phase II/III trial for Diabetic retinopathy
  • 06 Jun 2024 Ocuphire plans a phase II/III ZETA-2 pivotal trial for Diabetic retinopathy in early 2025
  • 18 May 2024 Pharmacodynamics data from the preclinical studies in Inflammatory bowel disease were presented at the Digestive Disease Week (DDW-2024)

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