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Fosbretabulin - Mateon Therapeutics

Drug Profile

Fosbretabulin - Mateon Therapeutics

Alternative Names: CA4DP; CA4P; Combretastatin A-4 phosphate - Mateon Therapeutics; Combretastatin A4 prodrug; Combretastatin-A4; Combretastatin-A4 phosphate; CRC 87-09; CRC-98-09; CS-A4; Fosbretabulin disodium; Fosbretabulin tromethamine; NSC-613729; Zybrestat®

Latest Information Update: 22 Aug 2019

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At a glance

  • Originator Arizona State University
  • Developer Mateon Therapeutics; National Cancer Institute (USA); OXiGENE; University of Aarhus; University of Florida; University of Kentucky
  • Class Antineoplastics; Combretastatins; Small molecules; Stilbenes
  • Mechanism of Action Cadherin 5 inhibitors; Tubulin polymerisation inhibitors; Vascular disrupting agents
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Ovarian cancer; Glioma; Thyroid cancer; Neuroendocrine tumours
  • New Molecular Entity Yes

Highest Development Phases

  • Preclinical Cancer
  • Discontinued Age-related macular degeneration; Colorectal cancer; Diabetic retinopathy; Fallopian tube cancer; Gastrointestinal cancer; Head and neck cancer; Leukaemia; Malignant carcinoid syndrome; Neuroendocrine tumours; Non-small cell lung cancer; Ovarian cancer; Pancreatic cancer; Peritoneal cancer; Polypoidal choroidal vasculopathy; Psoriasis; Rheumatoid arthritis; Thyroid cancer

Most Recent Events

  • 19 Oct 2018 Safety and efficacy data from a phase Ib/II trial in Ovarian cancer presented at the 43rd European Society for Medical Oncology Congress (ESMO-2018)
  • 14 Aug 2018 Mateon Therapeutics plans a phase IIa trial for Malignant melanoma (Late-stage disease, Combination therapy)
  • 24 Jun 2018 Biomarkers information updated
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