Drug Profile


Alternative Names: ADL 8-2698; ADL2698; Entereg; Entrareg; LY 246736; SB 767905

Latest Information Update: 04 Nov 2018

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At a glance

  • Originator Eli Lilly
  • Developer Adolor Corporation; Merck & Co
  • Class Gastrokinetics; Irritable bowel syndrome therapies; Piperidines; Small molecules
  • Mechanism of Action Opioid mu receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Postoperative ileus
  • Discontinued Constipation; Irritable bowel syndrome

Most Recent Events

  • 13 Apr 2016 Merck Sharp & Dohme and University Hospital Case Medical Center plan a phase III trial for Postoperative ileus in USA (PO) (NCT02742181)
  • 01 Jul 2015 Cubist Pharmaceuticals initiates enrolment in a phase II trial for Postoperative ileus in USA (NCT02379858)
  • 18 Mar 2015 Cubist Pharmaceuticals plans a phase II trial for Postoperative ileus in USA (NCT02379858).
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