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At a glance
Originator
Eli Lilly and Company
Developer
Eli Lilly; Eli Lilly and Company; John Wayne Cancer Institute; Merck Sharp & Dohme; University of California, Davis; Virginia Commonwealth University
Class
Antineoplastics; Benzamides; Glutamates; Hypoxanthines; Pyrimidines; Pyrroles; Small molecules
Mechanism of Action
Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Mesothelioma
New Molecular Entity
Yes
Highest Development Phases
Marketed
Mesothelioma; Non-small cell lung cancer
Phase II
Breast cancer
Phase I/II
Solid tumours
No development reported
Chordoma; Head and neck cancer; Non-Hodgkin's lymphoma; Osteosarcoma; Ovarian cancer; Renal cell carcinoma
Discontinued
Small cell lung cancer
Most Recent Events
28 Oct 2022
No recent reports of development identified for phase-I development in Chordoma in USA (IV, Infusion)
09 Sep 2022
Updated efficacy and adverse events data from the phase III KEYNOTE-189 trial in Non-small cell lung cancer presented at the 47th European Society for Medical Oncology Congress (ESMO-2022)
18 Feb 2022
Vitamin regimen patents for pemetrexed expires worldwide
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