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At a glance
Originator
Eli Lilly and Company
Developer
Eli Lilly; Eli Lilly and Company; John Wayne Cancer Institute; Merck Sharp & Dohme; University of California, Davis; Virginia Commonwealth University
Class
Antineoplastics; Benzamides; Glutamates; Hypoxanthines; Pyrimidines; Pyrroles; Small molecules
Mechanism of Action
Antimetabolites; Tetrahydrofolate dehydrogenase inhibitors; Thymidylate synthase inhibitors
Orphan Drug Status
Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.
Yes
-
Mesothelioma
New Molecular Entity
Yes
Highest Development Phases
Marketed
Mesothelioma; Non-small cell lung cancer
Phase II
Breast cancer
Phase I/II
Solid tumours
Phase I
Chordoma
No development reported
Head and neck cancer; Non-Hodgkin's lymphoma; Osteosarcoma; Ovarian cancer; Renal cell carcinoma
Discontinued
Small cell lung cancer
Most Recent Events
18 Feb 2022
Vitamin regimen patents for pemetrexed expires worldwide
12 Nov 2021
Amgen and M.D. Anderson Cancer Center plan a phase II trial for non-squamous Non-small cell lung cancer (Combination therapy, First-line therapy, Neoadjuvant therapy) in USA (IV), in March 2022 , (NCT05118854)
28 Feb 2021
No recent reports of development identified for phase-I development in Solid-tumours(Combination therapy, In the elderly, Inoperable/Unresectable, Late-stage disease, Metastatic disease, Second-line therapy or greater, In adults) in Australia (IV, Infusion)
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