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Tilarginine - Nova Pharmaceuticals

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Drug Profile

Tilarginine - Nova Pharmaceuticals

Alternative Names: 546C88; ANO-1020; BW546C88; L-NMMA; N-Monomethyl-arginine; NMA; TAI

Latest Information Update: 14 May 2026

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At a glance

  • Originator Cornell Research Foundation; Houston Methodist Hospital; M. D. Anderson Cancer Center
  • Developer Arginox Pharmaceuticals; Galera Therapeutics; Houston Methodist Hospital
  • Class Antihypotensives; Basic amino acids; Diamino amino acids; Small molecules; Vascular disorder therapies
  • Mechanism of Action Nitric oxide synthase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Cardiogenic shock
  • New Molecular Entity Yes

Highest Development Phases

  • Phase II Triple negative breast cancer
  • Phase I/II HER2 negative breast cancer
  • Discontinued Cancer; Cardiogenic shock; Hypotension; Kidney disorders; Rheumatoid arthritis; Septic shock; Transplant rejection

Most Recent Events

  • 31 Dec 2025 Galera Therapeutics has patents pending for tilarginine in Worldwide
  • 31 Dec 2025 Galera Therapeutics has patents protection for tilarginine in Worldwide
  • 07 Jan 2025 Phase-II clinical trials in Triple-negative-breast-cancer (Combination therapy) in USA (IV) before January 2025 (Galera therapeutics pipeline January 2025)

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