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Trastuzumab - Genentech

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Drug Profile

Trastuzumab - Genentech

Alternative Names: Anti-c-erbB-2 monoclonal antibody; Anti-erbB-2- monoclonal antibody; Anti-HER-2 monoclonal antibody; Anti-p185HER-2 monoclonal antibody; HER-2; HER-2 human monoclonal antibody; HER-2 MAb; HER-2 monoclonal antibody; HER-2 murine monoclonal antibody; HER-2/neu MAb; HER-2/neu monoclonal antibody; Herceptin; Herclon; Monoclonal antibody 4D5; R 597; RG597

Latest Information Update: 01 Mar 2024

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At a glance

  • Originator Genentech; Memorial Sloan-Kettering Cancer Center
  • Developer Chugai Pharmaceutical; Dana-Farber Cancer Institute; European Organisation for Research and Treatment of Cancer; FONDAZIONE DEL PIEMONTE PER L'ONCOLOGIA IRCC DI CANDIOLO; Genentech; Jiangsu Hengrui Medicine Co.; Roche; Sanofi; Shanghai Jiaotong University School of Medicine; West German Study Group; Yale University
  • Class Antineoplastics; Immunotherapies; Monoclonal antibodies
  • Mechanism of Action Antibody-dependent cell cytotoxicity; ERBB 2 receptor antagonists
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

    Yes - Salivary gland cancer
  • New Molecular Entity Yes

Highest Development Phases

  • Marketed Breast cancer; Gastric cancer
  • Registered HER2 positive breast cancer; Salivary gland cancer
  • Phase II Brain metastases; Colorectal cancer; Endometrial cancer
  • Discontinued Non-small cell lung cancer; Pancreatic cancer; Urogenital cancer

Most Recent Events

  • 18 Jan 2024 Efficacy data from a phase II trial in Gastric cancer presented at the 2024 Gastrointestinal Cancers Symposium (ASCO-GCS-2024)
  • 01 Nov 2023 MedSIR completes a phase-II trials in Breast cancer (Neoadjuvant therapy) in Belgium, France, Germany, Italy, Portugal, Spain, United Kingdom (IV) (NCT03161353) (EudraCT2016-002676-27)
  • 20 Oct 2023 Efficacy data from a phase II trial in Breast cancer presented at the 48th European Society for Medical Oncology Congress (ESMO-2023)

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