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Drug Profile


Alternative Names: 6-O-Butanoylcastanospermine; 60P 001; BuCast™; celgosivir hydrochloride; MBI-3253; MDL 28574; MDL 28574A; MX-3253; VIR 222

Latest Information Update: 23 Jan 2018

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At a glance

  • Originator sanofi-aventis
  • Developer 60 Degrees Pharmaceuticals Australia; Carrus Capital Corporation; Duke-NUS Graduate Medical School Singapore; Singapore General Hospital
  • Class Antivirals; Indolizines; Small molecules
  • Mechanism of Action Alpha-glucosidase inhibitors
  • Orphan Drug Status

    Orphan designation is assigned by a regulatory body to encourage companies to develop drugs for rare diseases.

  • New Molecular Entity Yes

Highest Development Phases

  • Phase I/II Dengue
  • Discontinued Hepatitis C; HIV infections

Most Recent Events

  • 23 Jan 2018 Celgosivir is still in phase I/II trials for Dengue in Singapore (60 Degree Pharmaceuticals pipeline, January 2018)
  • 11 Dec 2015 Celgosivir licensed to Knight Therapeutics in Canada, Israel and Russia
  • 19 Aug 2011 Discontinued - Phase-II for Hepatitis C in Canada (PO)
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